Studies show 'good' fat could work with weight loss pill

Fight fat with fat? The newest obesity theory suggests we may one day be able to do just that.

Just like good and bad cholesterol, there apparently are good and bad types of body fat. Scientists until recently believed this good fat, which spurs the body to burn calories to generate body heat, played an important role in keeping infants warm but by adulthood was mostly gone or inactive.

Now three studies -- from researchers in Boston, Finland and the Netherlands -- show that some good fat remains in adults, affecting metabolism and potentially offering a target to help people shed pounds.

Dr. Francesco Celi, an endocrinology and metabolism researcher at the National Institute of Diabetes and Digestive and Kidney Diseases, said the studies show this fat burns large amounts of energy.

"So it could be used as a target" for a pill that would somehow rev up the fat, he said.

Dr. Louis Aronne, former president of the Obesity Society and a weight control expert at Weill Cornell Medical Center in New York, said the findings are the most conclusive evidence so far of the role of such fat in regulating body temperature and weight.

"I don't want to use the word 'exercise-in-a-pill,' but it's doing something [that[']s] getting rid of calories," he said, adding that any obesity treatment developed around the fat could be a potential treatment for diabetes as well.

The studies were published in today's New England Journal of Medicine.

The good fat is brownish, while the more predominant bad fat is white or yellow. Brown fat is stored mostly around the neck and under the collarbone. White fat tends to concentrate around the waistline, where it stores excess energy and releases chemicals that control metabolism and the use of insulin.

All three research groups documented the presence and activity of the brown fat by examining tissue samples from some patients and using high-tech imaging that indicated how much sugar, and therefore calories, the fat burned.

One group from Joslin Diabetes Center, Harvard Medical School and three hospitals in Boston looked at scans done on nearly 2,000 patients to diagnose various health problems. The other two groups scanned small numbers of patients, first at room temperature and then after a couple of hours in mild cold, about 60 degrees.

Here's what the scientists learned about brown fat:

* Lean people had far more than overweight and obese people, especially among older folks.

* It burns far more calories and generates more body heat when people are in a cooler environment.

* Women were more likely to have it than men, and their deposits were larger and more active.

Finding a successful treatment for obesity would be a Holy Grail for scientists. Most obese and overweight people are unable to shed pounds and keep them off with dieting and exercise.

And despite plenty of effort, pharmaceutical companies have been unable to develop a medicine that helps people safely lose and keep off a significant amount of weight. Any drug that could do that would be a guaranteed blockbuster.

Aronne said the findings likely would renew interest in the area of brown fat among drugmakers; at least one briefly studied a treatment in lab animals several years ago.

So how could researchers use these basic findings about good fat to eventually come up with a weight-loss medication?

One possibility would be a pill to stimulate a specific protein to release more energy from the fat cells in the form of heat rather than storing it for future energy needs, Aronne and Celi said.

Finding a way to increase the amount of brown fat in a person would be another strategy. Researchers at Dana-Farber Cancer Institute in Boston have been injecting certain genes into mice to try to produce brown fat cells instead of white ones.

Celi said researchers also could try to make a pill that stimulates nerve endings inside brown fat to make it burn more calories.

Or overweight people could simply try turning down the thermostat to see if it makes them burn more energy and lose weight -- a strategy that Celi and researchers are testing in a small study that could produce results by the end of the year.

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On the Net:

New England Journal: http://www.nejm.org

Obesity Society: http://www.obesity.org