* Old Lorimier Cemetery: 500 N. Fountain St., established 1808, local registration, Sept. 21, 1992.
* Christian and Gladys Stiver House: 406 N. Louisiana St., built 1939, local registration, Jan. 1, 1993.
* Cape River Heritage Museum: 538 Independence St., built 1909, local registration, April 17, 1995.
* Hunze House: 312 Bellevue St., built 1891, local registration, July 24, 1995.
* Briney House: 25 N. Fountain St., built between 1904-1906, local registration, Nov. 20, 1995.
* Judith Ann Crow House: 323 Themis St., built 1821, local registration, Nov. 20, 1995; national registration, June 27, 1997.
* Whitelaw House: 423 Themis St., built 1890, local registration, March 18, 1996.
* Huhn-Harrison House: 340 S. Lorimier St., built 1906, local registration, March 18, 1996; national registration, June 27, 2002.
* D.A. Glenn House: 325 S. Spanish St., built 1883, local registration, Feb. 20, 1996; national registration, Oct. 11, 1979.
* St. Vincent de Paul Catholic Church: 131 S. Main St., built 1853; national registration, April 12, 1982; local registration, Feb. 20, 1996.
* Col. George C. Thilenius House: 100 Longview Drive, built 1871, national registration, March 29, 1983; local registration, Feb. 20, 1996.
* James Reynolds House: 623 N. Main St., built 1857, national registration, Oct. 13, 1983; local registration, Feb. 20, 1996.
* Hanover Lutheran Church: 2949 Perryville Road, built 1887, national registration, Aug. 25, 1987; local registration, June 17, 1996.
* George Boardman Clark House: 6 S. Fountain St., built 1882, national registration, July 22, 1994; local registration, Feb. 20, 1996.
* Klostermann Block (Alliance building): 715 S. Spanish St., built 1905, national registration, July 22, 1994; local registration, Feb. 20, 1996.
* Steinbeck-Brock House: 9 N. Fountain St., built circa 1842, local registration, Dec. 21, 1998.
* Freeman House: 24 N. Middle St., built 1911, local registration Jan. 19, 1999.
* Engelmann, Edward H. House: 504 Bellevue St., built 1894, local registration, Aug. 19, 2002.
National Register landmarks not on local register
* Oliver-Leming house: 740 North St., built 1898-99, national registration, 1979.
* Frederick W. Potts House: 823 Themis St., national registration, June 25, 1999.
* August and Amalia Shivelbine House: 303 S. Spanish St., built circa 1890, national registration June 25, 1999.
* Robert Felix Wichterich House: 300 Good Hope St., built 1906, national registration Aug. 12, 1999.
* Marquette Hotel: 338 Broadway, built 1928, national registration, April 11, 2002.
* H&H Building (Himmelberger and Harrison Building): 400 Broadway, built 1908, national registration, July 17, 2003.
* B'Nai Israel Synagogue: 126 S. Main St., built 1937,national registration, May 5, 2003.
* The Wood Building: 1-3 S. Frederick St. and 605-607 Independence St., national registration, Dec. 10, 2003.
National Register districts
* Cape Girardeau Commercial Historic District: located on the 100 block of North Main Street and the 100 block of Broadway.
* Haarig Commercial District: located on the 600 block of Good Hope Street and the 300 block of South Sprigg Street.
* Broadway and North Fountain Street Historic District: 320, 324, 338 and 400 Broadway, and 221 N. Fountain St.
* Warehouse Row Historic District: located at 19 N. Water St.
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