PARIS -- Andy Roddick failed to make it through the opening week at the French Open for the fifth time in as many tries, blowing a two-set advantage Thursday and a fifth-set lead against Argentine Jose Acasuso.
Roddick was broken twice after going ahead 3-1 in the last set and lost 3-6, 4-6, 6-4, 6-3, 8-6.
"I thought I had the better of him for the better part of three sets," Roddick said. "Unfortunately, the better part of three sets and three sets is something different."
Roddick's career record at Roland Garros fell to 4-5. His best showing was his first appearance in 2001, when he reached the third round.
The quintessential clay-court marathon began in 86-degree sunshine and ended 3 hours, 21 minutes later on a cloudy but muggy evening.
When Acasuso delivered the knockout blow, he sank to the court on his back in exhaustion and jubilation. Roddick climbed over the net to shake hands.
For the second year in a row -- and only the second time at a Grand Slam event in more than 30 years -- no American men made it out of the second round. James Blake and Vince Spadea also lost Thursday.
"It stinks," Roddick said. "I don't think any of us are happy. We all have a lot of pride, and it has gotten taken down a lot in the last couple of years here."
No. 3 Marat Safin beat qualifier Lukas Dlouhy 6-7 (6), 6-3, 7-5, 6-1; No. 32 Juan Carlos Ferrero, the 2003 champion, defeated Jan Hernych 6-4, 6-4, 6-2; and No. 8 Guillermo Coria, the 2004 runner-up, won when 18-year-old qualifier Novak Djokovic retired.
In women's play, Justine Henin-Hardenne advanced to the third round by beating Virginia Ruano Pascual 6-1, 6-4.
Maria Sharapova beat 18-year-old Frenchwoman Aravane Rezai 6-3, 6-2. Third-seeded Amelie Mauresmo of France defeated 15-year-old compatriot Alize Cornet 6-0, 6-2.
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