Most election results in surrounding Missouri counties mirrored results elsewhere in the state, and turnout was well above recent elections.
In Cape Girardeau County, 40,517 residents cast ballots, representing 73% of eligible voters. Perry County also turned out 73% of voters, 9,468. Sixty-nine percent of voters turned out in Bollinger and Scott counties.
Unofficial but complete vote totals from those counties were:
Cape Girardeau County
- President — Donald Trump, Republican, 28,873; Joe Biden, Democrat, 10,738; Jo Jorgensen, Libertarian, 519; Howie Hawkins, Green, 84; Don Blankenship, Constitution, 38.
- Governor — Mike Parson, Republican, 29,091; Nicole Galloway, Democrat, 10,257; Rik Combs, Libertarian, 627; Jerome Bauer, Green, 131.
- Lieutenant governor — Mike Kehoe, Republican, 28,905; Alissia Canady, Democrat, 9,764; Bill Slantz, Libertarian, 660; Kelley Gragoo, Green, 238.
- Secretary of state — John Ashcroft, Republican, 30,289; Yinka Faleti, Democrat, 8,364; Carl Freese, Libertarian, 724; Paul Venable, Constitution, 157; Paul Lehmann, Green, 202.
- State treasurer — Scott Fitzpatrick, Republican, 29,303; Vicki Englund, Democrat, 9,311; Nicholas Kasoff, Libertarian, 676; Joseph Civettini, Green, 172.
- Attorney general — Eric Schmitt, Republican, 29,352; Rich Finneran, Democrat, 9,216; Kevin Babcock, Libertarian, 9103.
- Amendment 1 — yes, 19,405; no, 19,165.
- Amendment 3 — yes, 24,210; no, 14,645.