The following is a listing of new business licenses issued by the city of Cape Girardeau and the Cape Girardeau County collector's office during the year 2000. Some franchises may list out-of-town or out-of-state addresses. All the county business licenses are for locations with Cape Girardeau addresses unless otherwise noted.
Cape Girardeau city
- State Collection, 334 Christine
- Regional Social Scene, 833 Broadway, Suite 101
- First Impressions, 125 S. Broadview
- Jurrock's Park Zoo and Pet Shop, 853 S. Kingshighway
- Moon Shadow Designs, Westfield Shoppingtown
- Gifts Galore, Westfield Shoppingtown
- Hot Wheels, 705 Broadway
- Needful Things, 200 Broadway
- Semo Auto Care, 101 S. Frederick
- Home Medical Supply, 760 S. Kingshighway
- Yard Occasions, 809 N. Park
- Sides Warehouse & Auction, 633 Good Hope
- Pharmedic Supplies, 839 N. Kingshighway
- Creative Office Solutions, 1427 Thomas
- Happy Hour Sports Bar, 118 Themis
- D-Mart #6, Farrar Drive
- Cape Shoe Co., 1600 S. Westend Boulevard
- Carolyn's Scrubs & Prints, 1636 Independence
- Fred's Dollar Store, corner of Sprigg and William
- Jimmy John's Deli, 1800 Broadway
- Cash For Less, 2711 Thomas
- Pretzel Time, 246A West Park Mall
- First USA Homes, 1930 Southern Expressway
- Burritoville, 1027 Broadway
- Piccadilly's, 97 N. Kingshighway
- Rhodes 101, 10 S. Westend Blvd.
- Cape Car & Truck Outlet, 566 S. Kingshighway
- SEMO Motor Co., 101 S. Frederick
- Tat-2000, 716 Broadway
- Lil's Treasures Island, 104 S. Sprigg
- America's Choice Transportation Service, 329 Edgewood
- Copeland Home Services, 42 N. Hanover
- AAA Auto Detailing, 30 S. Park
- R&S Contracting, 1700 Bloomfield Road
- EZ Divorce & Solution, 1459 Pemiscott
- Beautiful You Hair Salon, 512 Broadway
- Fantasies Forever Limousine Service, 1218 Dunklin
- Yoga Therapy Connection, 2828 Vista Lane
- Victoria's Secret, 3049 Williams
- Beach Bodies, 1420 N. Kingshighway
- Burrito-Ville, 1027 Broadway
- Cape Mini Storage, 1915 Golden Eagle Court
- Custom Computing, 2030 Montgomery
- Piccadilly's, 97 N. Kingshighway
- Pretzel Time, 3049 William
- Treasurable Moments, 127 N. Main
- Alt Haus Wieder (Old House Again), 509 Morgan Oak St.
- Candy Bouquet, 1744 Luce St.
- Enchanted Gift Gallery, 1700 David St.
- Meat Man Meats, 195 S. Pawnee St.
- Professional Real Estate Inspection, POB 367
- Riggins Enterprise LLC, 2707 Independence
- The Library, 701 N. Main St.
- Feelin & Lookin Good, 3049 William
- Gadzooks, 3049 William
- Health Priorities Inc., 35 Doctors' Park
- Heil Beauty Supply, 54 Plaza Way
- Love's Creation Salon, 110 S. Sprigg
- Breakaways, 13 N. Main
- Elias Ace Hardware, 1719 N. Kingshighway
- Physicians Billing Service, 2500 Tulip Lane
- Red Baron Web Design, 3123 Kage Road, Apt. B
- Bob Evans Restaurant, 156 Vantage
- Discyear, 3049 William
- Hair's Marilyn, 300 S. Mt. Auburn
- Houchin's Donuts, 1001 N. Kingshighway
- Platinum Sports Bar & Dance Club, 823 S. Kingshighway
- R&S Auto Sales, 1287 Independence
- S&S Auto Sales, 915 Broadway
- State Farm Insurance, 1900 Broadway
- Tans R Us, 91 S. Plaza Way
- Tel-Tech 2000, 1537 E. Riverside Dr.
- The Body's Solution, 5585 County Road 205
- Velosity Electronics, 229 Henderson
- We Maid It, 3457 William
- Albertson's, liquor license, 2126 Independence
- Albertson's Express, liquor license, 2134 Independence
- Mother's Blessings Massage, 2711 Thomas
- Otacom, 419 Broadway
Cape Girardeau County
- Midwest Energy Inc., Amerimart #7
- Billy Joe Glove Co., 175 Smoky Mountain Road, Jackson
- American Fire Protection, 811 August, Jackson
- Rhodes 101 Stop, Fruitland
- Gordonville Food & Fuel, 5700 Highway 25, Gordonville
- Borderline Bar & Grill, Pocahontas
- Reed's Zephyr Service Station, 102 Mason
- Cape Pizza Pro, 527 N. Silver Springs Road
- Creative Office Solutions, 1427 Thomas Drive
- Diamond Distributing, 120 Holly Circle, Jackson
- Affordable Merchandise, 10464 Highway 25, Dutchtown
- Holland Books, 1018 County Road 614
- Bloomin Balloons, 101 N. Kingshighway
- Mary's Antiques & Things, Oak Ridge
- Sew Unique, 633 Broadway
- Val's Upholstery, 121 W. Main, Jackson
- Quality Plumbing, Heating & A/C, 68 Sena Fawn Drive
- Murphy USA #5805, 3039 S. Jackson Boulevard, Jackson
- Thompson Auto Body, 4105 Highway 177
- Pender's Auto Repair & Exhaust, 141 N. Oklahoma, Jackson
- Cape Auto Pool, 1138 S. Kingshighway
- Carolyn's Scrubs & Prints, 1636 Independence
- Reid's Scrap Metal, 245 Smoky Mountain Road, Jackson
- Hobo Junction, Highways 61/25, Jackson
- Pretzel Time, 246A West Park Mall
- Great Cuts & Tans, 21826 Highway 177, Jackson
- One Fish Business, 1813 Randol
- Huckstep Body & Paint Shop, 1325 N. Kingshighway
- Delta-9, 2601 Janet Drive
- Gary's Car & Truck Sales, 506 S. Kingshighway
- Brooks Heating & Cooling, 142 Lindsay Lane, Jackson
- Muddy Waters II, 7570 Highway 177
- Poole's Gifts, 1437 N. Spanish
- Sign Art Studio, 3293 Highway 25, Jackson
- Rescue Beauty Supply, 225 Village Drive, Jackson
- Doctor's ValuVision, 3942 William
- Reflections By Marsha, 481 County Road 340, Jackson
- Cape Car & Truck Outlet, 566 S. Kingshighway
- Home Medical Supply of Poplar Bluff, 760 S. Kingshighway
- Kustom Carz, 10 Plaza Way
- Food Giant, 528 W. Main, Jackson
- R.C. Bruce & Co., 836 Dallas St., Jackson
- Jones & Miller Sales Co., 5854 Highway 61, Jackson
- Yard Occasions, 809 N. Park
- Invisible Fence of Southeast Missouri, 616 W. Adams
- Leemon Lounge, 18767 Highway 177, Jackson
- Anime Shoppe, 1030 Broadway
- Express Cycle Powersports, 1407 N. Kingshighway
- Telegrams, 144 Choctaw Lane, Jackson
- Heartland Banquet Hall, 101 Tower Circle Drive, Jackson
- Shade Tree Privacy Fences, 197 Estate Drive
- Custom Cable Services, 2850 Whitener
- Pro Line Nutrition, 8500 Highway D, Jackson
- Michelle's Hair Care, 5700 Highway 25, Gordonville
- The Furniture Barn, 18 N. Sprigg
- Comtech, 198 Hendrix Tulip Drive, Jackson
- Moonbeams, 240 Long Leaf Lane, Friedheim
- Elias Family Center, 1719 N. Kingshighway
- The Garden Gate, 3862 E. Jackson Blvd., Jackson
- Floor Brite Sports Flooring Co., Box 141 Delta
- Triple S' Firearms Co., 708 W. Main, Jackson
- Tanfastics, POB365, Jackson
- Discount Corner, 111 N. Sprigg
- Nelson General Sales, 272 Shoshone Lane
- Junior Sinn Auto Paarts, 588 County Road 649
- D&D Upholstery, 778 Enterprise
- Candy Bouquet, 1744 Luce St.
- Nostalgicdaze, 456 Shady Brook Drive, Gordonville
- Air Flow Industries, 823 N. Kingshighway
- Physicians Billing Service, 2500 Tulip Lane
- Big Rigs Refrigeration, 3359 Highway 74
- Eclipse Hair Studio, 38 N. Spanish
- Packaged Parties, 2763 County Road 610
- Feelin & Lookin Good, Westfield Shoppingtown
- Hair Port, 2033 Independence
- Gary's Garage, 209 S. Sprigg
- L & S Auto, 4581 Route Y, Jackson
- Huffman's Garage, 2680 County Road 458, Oak Ridge
- Miller Auction, 2980 Route V
- Brick Street Gallery, 5 N. Main St.
- Computer 21, 2010 Montgomery St.
- Pro Lube, 2300 E. Jackson Blvd., Jackson
- D&L Pest Control, 1403 N. Kingshighway
- A Complete Image, 635 Blanche Road
- Velosity Electronics, 229 N. Henderson
- Cape Precision Machine, 4925 Route W
Taken from the pages of Business Today.