Ultrasound method could mean fewer breast lump biopsies

~ Harmless lumps were distinguished from malignant ones with nearly 100 percent accuracy in study.

CHICAGO -- Finding a lump in the breast is a frightening moment for a woman, and under current methods of detecting cancer the anxiety can stretch out for weeks.

Doctors remove cells from the breast -- sometimes with a needle, sometimes with a scalpel -- to examine under a microscope. It can take days or longer for the costly, uncomfortable biopsies to produce results, frustrating women who want answers immediately.

That wait might shorten to minutes with an experimental, noninvasive technique: using ultrasound in a new way to tell the difference between cancerous tumors and harmless, or benign, lumps.

Elastography

In a small study of 80 women, the technique -- called "elastography" -- distinguished harmless lumps from malignant ones with nearly 100 percent accuracy.

If the results hold up in a larger study, thousands of unneeded biopsies might someday be eliminated. Up to 1 million biopsies are performed each year on suspicious breast tissue detected by mammograms and self-exams, but as many as eight out of 10 of these biopsies find that the lumps are benign.

"There's a lot of anxiety, a lot of stress, a lot of fear involved" with biopsies, said Susan Brown, manager of health education for the Susan G. Komen Breast Cancer Foundation. "And there's the cost of leaving work to make a second appointment. If this can be done instead of a biopsy, there would be a real cost reduction."

Biopsies can cost $200 to $1,000, depending on whether some fluid or an entire lump is removed, and it can take days or weeks to get the results. The cost of elastography is not yet clear, but some experts said the procedure might run $100 to $200. And it can yield results in minutes.

When checked against biopsies of women's breast tissue, the ultrasound technique correctly identified 17 out of 17 cancerous tumors, and 105 out of 106 harmless lesions. The findings were reported at a national radiology meeting in Chicago this week.

May have other uses

Scientists said the approach may also be used someday to rapidly diagnose damaged hearts and guide the treatment of prostate cancer.

The technique was pioneered during the 1990s at the University of Texas Medical School at Houston by Jonathan Ophir and his colleagues.

Ophir describes elastography as a way to measure and picture the elasticity of body tissue. In effect, it is an extension of one of the oldest tools in medicine, palpation, in which a doctor feels the shape and firmness of body tissue.

In traditional ultrasound, a doctor or technician places a handheld device on the skin that sends high-frequency sound waves into the body. Organs and tissue reflect the sound back as echoes, which are sent to a computer that turns them into a picture. Many people have seen ultrasound images of fetuses in the womb.

Elastography, though, also gauges movement. As the doctor moves the handheld device against the breast, the device collects echoes before and after the compression or movement of the breast tissue. The resulting images show stiff tissues as dark areas and soft tissues as light areas.

Breast cancer shows up larger on an elastogram than it does on a traditional ultrasound image, perhaps because the elastogram can "see" the scar tissue around the cancer, Ophir said.

"It's like finding a marble in Jell-O," said Dr. Richard Barr, a professor of radiology at Northeastern Ohio Universities College of Medicine who reported his findings at the Radiological Society of North America annual meeting. Germany-based Siemens AG provided the ultrasound equipment and software for Barr's study.

Ophir and other researchers said breast cancer diagnosis will be elastography's first real-world application.

"If it doesn't fly there, it won't fly anywhere," said Elisa Konofagou of Columbia University, who is testing elastography on animals and humans to determine the extent of damage after a heart attack. Uses in prostate cancer and thyroid cancer also are under study elsewhere.

Dr. Constantine Godellas, a cancer surgeon at Rush University Medical Center, said some patients and doctors would have trouble giving up biopsies, even if further research confirmed elastography's accuracy. Doctors may fear lawsuits if they do not order biopsies, he said.

"With the medical legal climate the way it is, that's a tough call to make," Godellas said. "It won't be until a lot more research has been done that people will really buy into it."

Dr. Ellen Mendelson, chief of breast imaging at Northwestern Memorial Hospital in Chicago, predicted the technique will be used, but may not supplant biopsies, which are becoming less invasive.

"The goal of reducing unnecessary biopsies is laudable, but you don't want to miss a cancer," Mendelson said.