WASHINGTON -- Alaska Sen. Lisa Murkowski turned against Supreme Court nominee Brett Kavanaugh quietly, uttering a single word: "No."
Sen. Susan Collins of Maine, her longtime friend and fellow moderate Republican, spoke on the Senate floor for 45 minutes, explaining her support for Kavanaugh in detail.
Though they reached opposite conclusions, both women had faced similar political pressure heading into Friday's key vote on Kavanaugh's high court nomination. As moderates who support abortion rights, their joint opposition could have been enough to sink Kavanaugh, whose nomination was thrust into uncertainty following sexual assault allegations.
Ultimately, it was Collins who put Kavanaugh on the brink of a lifetime appointment. Minutes after she finished speaking, West Virginia Democratic Sen. Joe Manchin said he, too, would back Kavanaugh, ensuring at least 51 "yes" votes in the Senate.
All three senators -- along with Arizona Republican Jeff Flake -- had been publicly undecided for weeks as they faced unrelenting pressure from both sides.
In the end, Collins and Murkowski diverged.
In a Senate speech disrupted by protesters before it began and met with applause from GOP senators when it ended, Collins declared, "I will vote to confirm Judge Kavanaugh."
Collins told a rapt Senate she does not believe that sexual assault allegations against Kavanaugh rise to a level to "fairly prevent" him from serving on the high court. Kavanaugh deserves a presumption of innocence, Collins said, and allegations by Christine Blasey Ford and other women did not reach a threshold of certainty.
Murkowski chose the opposite path.
"I believe that Brett Kavanaugh is a good man. It just may be that in my view he's not the right man for the court at this time," Murkowski told reporters after voting to oppose Kavanaugh in a procedural vote Friday morning.
While she respects her colleagues' support for Kavanaugh, Murkowski said, "I also that think we're at a place where we need to think about the credibility and integrity of our institutions."
Within minutes of their announcements, potential political challengers to both Collins and Murkowski emerged.
Former Alaska Gov. Sarah Palin insinuated she could run against Murkowski in a Republican primary, tweeting, ""Hey @lisamurkowski -- I can see 2022 from my house." The tweet was a reference to an infamous "Saturday Night Live" skit in which Tina Fey, portraying Palin, said she could see Russia from her house.
Susan Rice, the former national security adviser to President Barack Obama, volunteered herself on Twitter as a Democratic opponent to Collins in Maine. In a second tweet, she cautioned she was "not making any announcements" but was "deeply disappointed" in Collins' vote.
In the Capitol, however, both senators won praise from their colleagues.
"I think what Susan did today was rise to the occasion when the stakes were so high," said Sen. Lindsey Graham, R-S.C., one of Kavanaugh's most ardent supporters.
Flake said he thinks "the world" of Murkowski and said she made her own decision despite intense pressure to vote yes. "I admire her a lot," he said.
Murkowski's vote was the latest example of the independent streak she forged since overcoming a Republican primary challenge in 2010 to win re-election as a rare write-in candidate. She was re-elected in 2016.
Murkowski has expressed unease with the sexual assault allegations lodged against Kavanaugh, which he denies. She has faced pressure from home state Alaskans, including Native Alaskan women, who have described the scourge of sexual assault.
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