She was born Jan. 21, 1944, in Gideon, Mo., daughter of the late Randall and Ernestine Lewis Pool. She and Charles Picou were married July 2, 1988.
Survivors include her husband; two daughters, Yvette (Joe) Hoeckele of Perryville, Tina (Jimmy) Castelli of Collinsville, Ill.; five stepchildren, Charles (Kelly) Picou, Melanie (Toby) Taylor, Matthew Picou, Sara (Brian) Johnson, all of Perryville, Susannah (Chris) Rahlman of Poplar Bluff, Mo.; two sisters, Priscilla (Ronald) Zahner, Beth (Kenny) Loness of Perryville; 16 grandchildren; and two great-grandchildren.
She was preceded in death by her parents and a brother, Randy Pool.
Mrs. Picou was a retired custodian at Sabreliner Corp.
Visitation will be from 4 to 9 p.m. Friday and 6:30 a.m. until time of service Saturday at Young and Sons Funeral Home.
The funeral will be at 10 a.m. at the funeral home, with the Rev. John Chamness officiating. Burial will be in Mount Hope Cemetery.
Memorials are preferred to American Cancer Society or American Diabetes Association.