Sen. Hillary Rodham Clinton, D-N.Y., speaks during a confirmation hearing for her nomination as secretary of state as her daughter, Chelsea Clinton, watches Jan. 13 before the Senate Foreign Relations Committee on Capitol Hill in Washington, D.C. The Senate has confirmed Hillary Clinton to become secretary of state.
The Senate voted 94-2, with Republican Sens. David Vitter of Louisiana and Jim DeMint of South Carolina opposing.
Republicans and Democrats alike said her swift confirmation was necessary so Obama could begin tackling the major foreign policy issues at hand, including two wars, increased violence in the Middle East and the threat of a nuclear-armed Iran.
"It is essential that we provide the president with the tools and resources he needs to effect change, and that starts with putting a national security team in place as soon as possible," said Sen. John Kerry, D-Mass., chairman of the Foreign Relations Committee.
Obama's presidential rival, Sen. John McCain, was among those who spoke in Clinton's favor.
"This nation has come together in a way that it has not for some time," said the Arizona Republican, on the Senate floor for the first time since the inauguration.
Voters "want us to work together and get to work," McCain said.
As the Senate debated Clinton's appointment, Obama wasted no time in his first day at the White House. The administration planned to name former Senate Democratic leader George J. Mitchell as Clinton's special envoy for the Middle East. Dennis Ross, a longtime U.S. negotiator, was also expected to advise Clinton on Mideast policy, according to officials who spoke on condition of anonymity because they were not authorized to speak publicly about the move.
Clinton planned to report to the State Department today, where she was expected to address employees in the main lobby in the morning -- a tradition of sorts for state secretaries on their first day on the job.
The former first lady received overwhelming bipartisan support in Congress despite lingering concerns by some Republicans that her husband's charitable fundraising overseas could pose conflicts of interest.
Sen. Richard Lugar, the ranking Republican on the Foreign Relations Committee, proposed that former president Bill Clinton's foundation reject foreign contributions. But Hillary Clinton rejected Lugar's proposal, contending that the foundation's plan to disclose annually its list of donors and a range of its contributions already exceeds legal requirements.
Lugar said he hoped Clinton would re-examine her position but supported her appointment, citing her "remarkable qualifications" and "pressing global issues."
Vitter and DeMint, both members of the Senate Foreign Relations Committee, said they were unsatisfied. Last week, Vitter cast the sole opposing vote in the committee's 16-1 endorsement of Clinton. DeMint voted in favor of Clinton on the committee because he said he didn't want to obstruct a full Senate vote on her appointment, but ultimately did not support her nomination.
Following the vote, the Senate Foreign Relations Committee endorsed Susan Rice to become U.S. ambassador to the United Nations, a post Obama has elevated to the Cabinet level.
Meanwhile, the Senate considered other appointments by Obama.
Treasury Secretary-designate Timothy Geithner apologized to the Senate Finance Committee and said he was careless for failing to pay $34,000 in Social Security and Medicare taxes earlier this decade. The committee planned to vote on his appointment on Thursday.
Eric Holder's bid to become the first African-American attorney general was delayed for at least a week when Republicans demanded more time to question him about harsh interrogations, Guantanamo trials and other topics.
Associated Press writers Barry Schweid, Martin Crutsinger and Larry Margasak contributed to this report.