British adventurer Neil Laughton, front, poses with his Parajet Skycar with his team Tuesday in London during the launch of the expedition in his Parajet Skycar from London to Timbuktu.
The vehicle, which looks like a dune buggy with a huge fan and a paragliding wing attached, is called the Parajet Skycar.
It was designed by self-taught engineer and inventor Giles Cardozo to fly at up to 70 mph and drive at about 120 mph.
"You jump into the driver's seat, open up the throttle, the fan spins up, the wind launches, and you just accelerate down the runway and within 50 to 100 yards you're flying, you just take off," he said.
It is billed as the world's first legal, biofuelled flying car, but its voyage to Timbuktu will be backed up by a large ground support team with a number of traditional cars, trucks and all-terrain vehicles.
The plan is to drive where there are roads, but to fly over the Strait of Gibraltar, the Atlas Mountains in Morocco and large trackless portions of the Sahara Desert.
Cardozo said the light craft cannot fly in foul weather.
"It's not an all-weather machine," he said. "You don't want to be flying in the rain, in the wind, too much. It's more of a fun toy than the ultimate means of transport."
The vehicle becomes airborne when the strong fan pushes the car forward at increasing speeds and the wing provides enough lift to get the Skycar off the ground.
Most of the flying will be done by ex-Special Air Service man Neil Laughton.
Before departure, Laughton, 45, said he looked forward to landing the flying car in small West African villages.
"I just can't wait to see their faces when we fly in and start playing football with them," he said. "I don't think they will be able to believe somebody in a flying car has just visited them."
The Parajet Skycar can be steered with cables to change the wing's shape. It is designed to survive engine failure by using the wing like a parachute that would allow the car to drift slowly toward the ground.
The planned trip is 3,600 miles long. The adventurers hope to arrive in Timbuktu on Feb. 20 after traveling through England, France, Spain, Morocco, the Western Sahara, and Mali.
The organizers hope to raise about $100,000 for charity during the journey.