O'Brien is a 1999 graduate of Oakville Senior High School. She received bachelor of science and master of arts degrees from Southeast Missouri State University. She is a speech/language pathologist with the Special School District of St. Louis County.
Smith is a 1997 graduate of Central High School in Cape Girardeau. He received a degree from Southeast Missouri Hospital College of Nursing and Health Sciences. He is a radiological technologist at Missouri Baptist Medical Center.
A Sept. 29 wedding is planned at Queen of All Saints Church in St. Louis.