(BRETT COOMER ~ Associated Press)
Rookie Maurice Drew ran for a career-high 166 yards and two touchdowns, had a 93-yard kickoff return for a score, and the Jaguars (8-5) literally ran the Colts (10-3) out of town and maybe out of contention for home-field advantage in the AFC.
Fred Taylor was equally effective against the league's worst run defense, gaining 131 yards on nine carries before leaving with a sore right hamstring.
The Colts allowed a franchise record 375 yards rushing. Indy's Marvin Harrison became the fourth player in NFL history with 1,000 receptions Sunday, joining Jerry Rice, Tim Brown and Cris Carter. Harrison had six catches for 101 yards.
Saints 42, Cowboys 17
Having spent the last three years on Parcells' staff, Dennis Payton knew exactly how to attack the Cowboys -- and Drew Brees pulled it off perfectly, tying his career high with five touchdown passes, all before the third quarter ended.
Brees finished 26-of-38 for 384 yards, all without throwing a pass in the fourth quarter.
The Saints (9-4) grabbed sole possession of the second-best record in the NFC.
The Cowboys (8-5) had won their last four games.
Dolphins 21, Patriots 0
Miami sacked Tom Brady four times, forced him to fumble twice, held him to 78 yards passing and shut out the Patriots for the first time since the perfect-season Dolphins of 1972.
The Patriots (9-4) still lead the AFC East, but the loss hurt their chances of earning a first-round bye in the playoffs. They lost on the road for the first time in six games this season.
Miami (6-7), virtually eliminated from the playoff race a week ago, won for the fifth time in six games.
Titans 26, Texans 20, OT
Vince Young ran for a 39-yard touchdown in overtime for a third straight comeback victory and fourth win in a row.
Two weeks ago, the Titans (6-7) rallied from a 21-0 deficit in the final 91/2 minutes to beat the Giants. Last week, Rob Bironas' 60-yard field goal in the final seconds beat Indianapolis.
Bengals 27, Raiders 10
Carson Palmer threw for a pair of touchdowns and Rudi Johnson ran for two more to strengthen Cincinnati's playoff chances.
The Bengals (8-5) have won four in a row, moving to the forefront of the AFC wild card race.
Two Bengals receivers -- T.J. Houshmandzadeh and Chad Johnson topped 100 yards, and a running back also ran for 100 yards -- Johnson had 117 yards -- the first time that has happened in franchise history.
Eagles 21, Redskins 19
The Eagles intercepted two passes -- one was returned 84 yards for a TD by Michael Lewis -- and Jeff Garcia threw two TD passes.
Garcia was threw for 164 yards in another solid outing to improve to 2-1 as the starter since Donovan McNabb's season-ending injury. The Eagles improved to 7-6.
Ravens 20, Chiefs 10
Steve McNair hooked up with Mark Clayton for an 87-yard score and Ed Reed had two interceptions Sunday, leading the Ravens.
Baltimore (10-3) maintained its two-game AFC North lead over Cincinnati, which beat Oakland.
The Ravens forced three turnovers and sacked Trent Green four times.
Vikings 30, Lions 20
Artose Pinner had career highs with 125 yards rushing and three touchdowns to lift the Vikings (6-7).
The Lions (2-11) have lost five straight.
Falcons 17, Buccaneers 6
The NFL's top rushing team lost Warrick Dunn and Jerious Norwood within a span of five plays of the third quarter, but Justin Griffith came in to finish a 71-yard drive with a 21-yard touchdown burst to lead Atlanta (7-6).
Dunn injured his calf after gaining 9 yards to boost his season total to 997. Norwood hurt his right knee four plays later.
Giants 27, Panthers 13
Tiki Barber rushed for 112 yards, Eli Manning threw three touchdown passes and the Giants (7-6) snapped a four-game losing streak.
Chris Weinke, making his first start in more than four years in place of the injured Jake Delhomme, threw for a team-record 423 yards, but had three second-half interceptions for the Panthers (6-7), losers of three straight.
Cardinals 27, Seahawks 21
Edgerrin James topped 100 yards rushing for the second game in a row and Matt Leinart threw touchdown passes of 56 and 5 yards to lead the Cardinals (4-9) to their third victory in four games.
Seattle (8-5) lost three fumbles resulting in 14 Arizona points, including Leinart's 5-yard scoring pass to Larry Fitzgerald for the go-ahead score on the first play of the fourth quarter.
Bills 31, Jets 13
Willis McGahee scored on a 57-yard run, Lee Evans had a 77-yard TD catch and Nate Clements returned an interception 58 yards for a score.
Buffalo (6-7) looked more like the playoff contender than the Jets (7-6), winning for the third time in four games.
McGahee had 125 yards and a touchdown on 16 carries.
Packers 30, 49ers 19
Brett Favre passed for 293 yards and hit Donald Driver for a 68-yard touchdown, and the Packers (5-8) snapped a three-game losing streak.
Favre went 22-for-34 and surpassed 3,000 yards passing for the 15th straight season to extend his own NFL record.
-- The Associated Press