Peyton Manning is back to throwing touchdowns and the Indianapolis Colts are again achieving offensive milestones.
The NFL's two-time MVP carved up Houston (1-8) for 297 yards and three touchdowns Sunday, leading the Colts (9-0) to a victory and keeping Indianapolis as the NFL's only unbeaten team.
Manning completed 26 of 35 passes, while Marvin Harrison had seven catches for 108 yards and one TD, making Manning and Harrison the only tandem to top 10,000 career yards.
Nathan Vasher returned a missed field goal 108 yards for a TD, the longest play in NFL history, and the Chicago Bears won their fifth straight.
The previous longest play was Baltimore's Chris McAlister's 107-yarder with a missed field goal in 2002. The Bears (6-3) have their longest winning streak since 2001.
Cody Pickett, at one time a fourth stringer quarterback for the 49ers (2-7) finished 1-for-13.
The Vikings became the first team in NFL history to get touchdown returns on a punt, a kickoff and an interception.
Then quarterback Brad Johnson finally put together a drive, setting up Paul Edinger's 48-yard field goal with 10 seconds remaining.
Safety Darren Sharper had three interceptions for the Vikings (4-5). Eli Manning finished 23-of-48 for 291 yards for the Giants (6-3).
Tom Brady brought New England (5-4) from behind twice in the second half, throwing a 17-yard TD pass to Benjamin Watson for the winning score with 2:16 left. Gus Frerotte drove the Dolphins (3-6) 70 yards to the 5 with a minute left, but his fourth-down pass was incomplete with 36 seconds to go.
J.P. Losman, taking over after Kelly Holcomb hurt his head in the second quarter, led the Bills ((4-5) to touchdown drives on two of his first four possessions.
The Bills' defense limited the Chiefs (5-4) to 316 yards while generating three interceptions, a fumble and six sacks.
Greg Jones ran for a career-high 106 yards and a touchdown, Matt Jones had a career-high 117 yards receiving and a score and the Jaguars (6-3) reached 30 points for the first time since 2001.
The Ravens (2-7) lost their fourth consecutive game.
Roy Williams caught a career-high three touchdown passes from Joey Harrington as Detroit (4-5) ended a two-game losing streak and Arizona (2-7) lost its third straight.
Williams, playing an entire game for the first time since Oct. 2, had seven receptions for 117 yards and caught TD passes of 7, 21 and 29 yards.
Somehow, Mike Alstott found a way into the end zone on a gutsy 2-point conversion call by coach Jon Gruden.
Alstott's run with 58 seconds remaining came after the Redskins (5-4) blocked a potential game-tying extra point, only to be penalized for being offside on the previous play. Alstott was hit at the line and appeared stopped before twisting and keeping his legs moving to barely get into the end zone. The conversion stood after the replay official's review.
Chris Simms threw for 279 yards and two touchdowns for the Bucs (6-3), including a 30-yarder to Edell Shepherd that set up the exciting finish.
Nigerian-born Samkon Gado ran for 103 yards and scored three touchdowns as the Packers (2-7) won for the second time this season.
The Falcons (6-3) had six fumbles on the day.
Jake Plummer passed for 205 yards and a touchdown, had no interceptions and wasn't sacked all day, and Jason Elam kicked three field goals for Denver.
Darrent Williams returned an interception 80 yards for a fourth-quarter score that ended Oakland's chance at a comeback. The Broncos (7-2) took a two-game division lead after the Kansas City Chiefs lost 14-3 at Buffalo.
Kerry Collins had his worst game of the year for Oakland (3-6), completing 26 of 50 passes for 310 yards, doubled his season total with three interceptions and was sacked four times.
Will Witherspoon returned an interception 35 yards for a touchdown and Ken Lucas grabbed two of Carolina's four interceptions.
Carolina (7-2) forced six turnovers by the Jets (2-7) to pull away after an uneventful first half. The Panthers scored 20 points off turnovers.
Charlie Batch improvised a 1-yard touchdown run late in the second quarter, and his passing led to another score before he left with a broken right hand.
Tommy Maddox replaced Batch to run an efficient and time-consuming offense in the second half, and college QB-turned-wide receiver Antwaan Randle El threw a 51-yard scoring pass to Hines Ward on a reverse early in the third quarter to put the Steelers (7-2) up 24-7.
-- From wire reports