Two weak systems could bring a chance of snow on Friday and again over the weekend.
The first system will probably only bring flurries on Friday. I'd be surprised if we got more than a dusting.
The second system, which I'm tentatively calling Winter Storm "Eddie", is forecasted to arrive Saturday night as an Albert Clipper. It's rare for a clipper to bring a major snow, but Eddie does have the potential to deliver a moderate 1-4 inch snowfall at Cape Girardeau.
As you'll recall, our very first snow of the year (1½-2 inches) was brought by an Alberta Clipper on Jan. 6-7. The computer models are suggesting that Eddie could be slightly stronger, but there's no reason to ransack the stores again.
(The GFS model tries to bring some freezing rain Saturday night, but I'm going to pretend I didn't see that.)
The cold weather should last well into next week. If you're sick of snow, then just be thankful this isn't Washington, D.C. The city shattered its all-time snowfall record today with a grand total of 54.9 inches for the season.