Madonna performs in Seattle as she opens her first national tour April 10, 1985.

When we were 5 years old...

Sean Penn and his wife, singer Madonna, chat with reporters prior to the screening of Penn's new movie "At Close Range" on April 17, 1986, in Los Angeles.

Madonna's 1986 album "True Blue" included the songs "Papa Don't Preach", "Live To Tell" and "Open Your Heart".

When we were 9...

Madonna performs during her Blond Ambition tour July 20, 1990, in Wembly Stadium in London.

In 1990, Madonna released "The Immaculate Collection", a greatest-hits album including "Holiday", "Like A Virgin", "Material Girl", "Justify My Love", "Like A Prayer" and "Vogue" among others.

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When we were 10...

Madonna leaves the screening of her movie "Truth or Dare" on May 14, 1991, at the 44th Cannes Film Festival in France.

Wow. What an outfit. Weren't there any "Worst Dressed" lists back then? Yikes.

When we were 20...

Madonna performs June 19, 2001, in Berlin during her "Drowned World Tour."

After a string of projects in the 1990s ("Bedtime Stories", "Evita", "Something To Remember" and "Ray of Light", just to name a few), Madonna released GHV2, her second greatest-hits collection. "Erotica" and "Take A Bow" made an appearance on this album.

The kiss seen round the world

Britney Spears, left, and Madonna kiss during the opening performance of the MTV Video Music Awards on Aug. 28, 2003, at New York's Radio City Music Hall.

Britney kisses Madonna at the VMAs... How long after that was it that Brit started losing it? Hm. Maybe there's no connection...

Saving the world one Malawian boy at a time.

Madonna arrives for the 2008 amfAR Cinema Against AIDS benefit May 22, 2008, in Mougins, southern France.

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